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客員教授 岸本健雄
特任リサーチフェロー 平岡大作
事務補佐員 多田優美子



48. Hiraoka, D., Hosoda, E., Chiba, K., and Kishimoto, T. (2019). SGK phosphorylates Cdc25 and Myt1 to trigger cyclin B-Cdk1 activation at the meiotic G2/M transition. J. Cell Biol., 218, 3597-3611.

47. Hosoda, E., Hiraoka, D., Hirohashi, N., Omi, S., Kishimoto, T., and Chiba, K. (2019). SGK regulates pH increase and cyclin B-Cdk1 activation to resume meiosis in starfish ovarian oocytes. J. Cell Biol., 218, 3612-3629.

46. Takeda, N., Kon, Y., Quiroga Artigas, G., Lapebie, P., Barreau, C., Koizumi, O., Kishimoto, T., Tachibana, K., Houliston, E., and Deguchi, R. (2018). Identification of jellyfish neuropeptides that act directly as oocyte maturation inducing hormones. Development, 145, dev.156786 , doi: 10.1242/dev.156786.

45. Hiraoka, D., Aono, R., Hanada, S., Okumura, E., and Kishimoto, T.(2016). Two new competing pathways establish the threshold for cyclin B-Cdk1 activation at the meiotic G2/M transition. J. Cell Sci., 129, 3153-3166.

44. Okumura, E., Morita, A., Wakai, M., Mochida, S., Hara, M., and Kishimoto, T.(2014). Cyclin B-Cdk1 inhibits protein phosphatase PP2A-B55 via a Greatwall kinase-independent mechanism. J. Cell Biol., 204, 881-889 (selected In This Issue).

43. Ucar, H., Tachibana, K., and Kishimoto, T.(2013). The Mos-MAPK pathway regulates Diaphanous-related formin activity to drive cleavage furrow closure during polar body extrusion in starfish oocytes. J. Cell Sci., 126, 5153-5165.

42. Hara, M., Abe, Y., Tanaka, T., Yamamoto, T., Okumura, E., and Kishimoto, T.(2012). Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase promoting factor. Nat. Commun., 3:1059, doi: 10.1038/ncomms2062.

41. Hiraoka, D., Okumura, E. and Kishimoto, T.(2011). Turn motif phosphorylation negatively regulates activation loop phosphorylation in Akt. Oncogene, 30, 4487-4497.

40. Abe, Y., Okumura, E., Hosoya, T., Hirota, T. and Kishimoto, T.(2010). A single starfish Aurora kinase performs the combined functions of Aurora-A and Aurora-B in human cells. J. Cell Sci., 123, 3978-3988.

39. Tachibana, K., Mori, M., Matsuhira, T., Karino, T., Inagaki, T., Nagayama, A., Nishiyama, A., Hara, M. and Kishimoto, T.(2010). Initiation of DNA replication after fertilization is regulated by p90Rsk at pre-RC/pre-IC transition in starfish eggs. Proc. Natl. Acad. Sci. USA, 107, 5006-5011.

38. Hara, M., Mori, M., Wada, T., Tachibana, K. and Kishimoto, T.(2009). Start of the embryonic cell cycle is dually locked in unfertilized starfish eggs. Development, 136, 1687-1696.

37. Tachibana, K., Hara, M., Hattori, Y. and Kishimoto, T.(2008). Cyclin B-Cdk1 controls pronuclear union in interphase. Curr. Biol., 18, 1308-1313.

36. Gotoh, T., Shigemoto, N. and Kishimoto, T.(2007). Cyclin E2 is required for embryogenesis in Xenopus laevis. Dev. Biol., 310, 341-347.

35. Nishiyama, T., Yoshizaki, N., Kishimoto, T.and Ohsumi, K. (2007). Transient activation of calcineurin is essential to initiate embryonic development in Xenopuslaevis. Nature, 449, 341-345.

34. Nishiyama, T., Ohsumi, K. and Kishimoto, T.(2007). XErp1 phosphorylation by p90Rsk is required for cytostatic factor arrest in Xenopuseggs. Nature, 446, 1096-1099.

33. Mori, M., Hara, M., Tachibana, K. and Kishimoto, T.(2006). p90Rsk is required for G1 phase arrest in unfertilized starfish eggs. Development, 133, 1823-1830.

32. Yamamoto, T.M., Iwabuchi, M., Ohsumi, K. and Kishimoto, T.(2005). APC/C-Cdc20-mediated degradation of cyclin B participates in CSF arrest in unfertilized Xenopuseggs. Dev. Biol., 279, 345-355.

31. Hiraoka, D., Hori-Oshima, S., Fukuhara, T., Tachibana, K, Okumura, E. and Kishimoto, T.(2004). PDK1 is required for the hormonal signalling pathway leading to meiotic resumption in starfish oocytes. Dev. Biol., 276, 330-336.

30. Ohsumi, K., Koyanagi, A., Yamamoto, T.M., Gotoh, T. and Kishimoto, T.(2004). Emi1-mediated M-phase arrest in Xenopus eggs is distinct from cytostatic factor arrest. Proc. Natl. Acad. Sci. USA, 101, 12531-12536.

29. Okano-Uchida, T., Okumura, E., Iwashita, M., Yoshida, H., Tachibana, K. and Kishimoto, T.(2003). Distinct regulators for Plk1 activation in starfish meiotic and early embryonic cycles. EMBO J., 22, 5633-5642.

28. Iwabuchi, M., Ohsumi, K., Yamamoto, T. M. and Kishimoto, T.(2002). Coordinated regulation of M phase exit and S phase entry by the Cdc2 activity level in the early embryonic cell cycle. Dev. Biol., 243, 34-43.

27. Okumura, E., Fukuhara, T., Yoshida, H., Hanada, S., Kozutsumi, R., Mori, M., Tachibana, K. and Kishimoto, T.(2002). Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition. Nature Cell Biol., 4, 111-116.

26. Gotoh, T., Ohsumi, K., Matsui, T., Takisawa, H. and Kishimoto, T.(2001). Inactivation of the checkpoint kinase Cds1 is dependent on cyclin B-Cdc2 kinase activation at the meiotic G2/M-phase transition in Xenopusoocytes. J. Cell Sci., 114, 3397-3406.

25. Tachibana, K., Tanaka, D., Isobe, T. and Kishimoto, T.(2000). c-Mos forces the mitotic cell cycle to undergo meiosis II to produce haploid gametes. Proc. Natl. Acad. Sci. USA, 97, 14301-14306.

24. Nishiyama, A., Tachibana, K., Igarashi, Y., Yasuda, H., Tanahashi, N., Tanaka, K., Ohsumi, K. and Kishimoto, T.(2000). A non-proteolytic function of the proteasome is required for the dissociation of Cdc2 and cyclin B at the end of M-phase. Genes Dev., 14, 2344-2357.

23. Iwabuchi, M., Ohsumi, K., Yamamoto, T. M., Sawada, W. and Kishimoto, T.(2000). Residual Cdc2 activity remaining at meiosis I exit is essential for meiotic M-M transition in Xenopusoocyte extracts. EMBO J., 19, 4513-4523.

22. Okano-Uchida, T., Sekiai, T., Lee, K., Okumura, E., Tachibana, K. and Kishimoto, T.(1998). In vivoRegulation of cyclin A/Cdc2 and cyclin B/Cdc2 through meiotic and early cleavage cycles in starfish. Dev. Biol., 197, 39-53.

21. Ookata, K., Hisanaga, S., Sugita, M., Okuyama, A., Murofushi, H., Kitazawa, H., Chari, S., Bulinski, J. C. and Kishimoto, T.(1997). MAP4 is the in vivo substrate for cdc2 kinase in HeLa cells--- Identification of an M-phase specific and a cell cycle-independent phosphorylation site in MAP4---. Biochemistry, 36, 15873-15883.

20. Tachibana, K., Machida, T., Nomura, Y. and Kishimoto, T.(1997). MAP kinase links the fertilization signal transduction pathway to the G1/S-phase transition in starfish eggs. EMBO J., 16, 4333-4339.

19. Okumura, E., Sekiai, T., Hisanaga, S., Tachibana, K. and Kishimoto, T.(1996). Initial triggering of M-phase in starfish oocytes: A possible novel component of MPF besides cdc2 kinase. J. Cell Biol., 132, 125-135.

18. Hisanaga, S., Uchiyama, M., Hosoi, T., Yamada, K., Honma, N., Ishiguro, K., Uchida, T., Dahl, D., Ohsumi, K. and Kishimoto, T.(1995). Porcine brain neurofilament-H tail domain kinase: its identification as CDK5/p26 complex, and comparison with CDC2/cyclin B kinase. Cell Motil. Cytoskel., 31, 283-297.

17. Ookata, K., Hisanaga, S., Bulinski, J. C., Murofushi, H., Aizawa, H., Itoh, T. J., Hotani, H., Okumura, E., Tachibana, K., and Kishimoto, T.(1995). Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics. J. Cell Biol., 128, 849-862.

16. Ohsumi, K., Sawada, W. and Kishimoto, T.(1994). Meiosis-specific cell cycle regulation in maturing Xenopusoocytes. J. Cell Sci., 107, 3005-3013.

15. Ohsumi, K., Katagiri, Ch. and Kishimoto, T.(1993). Chromosome condensation in Xenopusmitotic extracts without histone H1. Science, 262, 2033-2035.

14. Ookata, K., Hisanaga, S., Okumura, E. and Kishimoto, T.(1993). Association of p34cdc2/cyclin B complex with microtubules in starfish oocytes. J. Cell Sci., 105, 873-881.

13. Ookata, K., Hisanaga, S., Okano, T., Tachibana, K. and Kishimoto, T.(1992). Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes. EMBO J., 11, 1763-1772.

12. Hisanaga, S., Kusubata, M., Okumura, E. and Kishimoto, T.(1991). Phosphorylation of neurofilament H subunit at the tail domain by CDC2 kinase dissociates the association to microtubules. J. Biol. Chem., 266, 21798-21803.

11. Tachibana, K., Ishiura, M., Uchida, T. and Kishimoto, T.(1990). The starfish egg mRNA responsible for reinitiation of meiotic maturation encodes cyclin. Dev. Biol., 140, 241-252.

10. Shilling, F., Chiba, K., Hoshi, M., Kishimoto, T.and Jaffe, L. A. (1989). Pertussis toxin inhibits 1-methyladenine-induced maturation in starfish oocytes. Dev. Biol., 133, 605-608.

9. Hashimoto, N. and Kishimoto, T.(1988). Regulation of meiotic metaphase by a cytoplasmic maturation-promoting factor during mouse oocyte maturation. Dev. Biol., 126, 242-252.

8. Tachibana, K., Yanagishima, N. and Kishimoto, T.(1987). Preliminary characterization of maturation-promoting factor from yeast Saccharomyces cerevisiae. J. Cell Sci., 88, 273-281.

7. Kishimoto, T.and Kondo, H. (1986). Extraction and preliminary characterization of maturation-promoting factor from starfish oocytes. Exp. Cell Res., 163, 445-452.

6. Kishimoto, T., Yamazaki, K., Kato, Y., Koide, S. S. and Kanatani, H. (1984). Induction of starfish oocyte maturation by maturation-promoting factor of mouse and surf clam oocytes. J. Exp. Zool., 231, 293-295.

5. Kishimoto, T., Usui, N. and Kanatani, H. (1984). Breakdown of starfish ovarian follicle induced by maturation-promoting factor. Dev. Biol., 101, 28-34.

4. Kishimoto, T., Kuriyama, R., Kondo, H. and Kanatani, H. (1982). Generality of the action of various maturation- promoting factors. Exp. Cell Res., 137, 121-126.

3. Kishimoto, T., Hirai, S. and Kanatani, H. (1981). Role of germinal vesicle material in producing maturation-promoting factor in starfish oocyte. Dev. Biol., 81, 177-181.

2. Kishimoto, T.and Kanatani, H. (1976). Cytoplasmic factor responsible for germinal vesicle breakdown and meiotic maturation in starfish oocyte. Nature, 260, 321-322.

1. Kishimoto, T. and Kanatani, H. (1973). Induction of starfish oocyte maturation by disulfide-reducing agents. Exp. Cell Res., 82, 296-302


21. Murabe, N., Okumura, E., Chiba, K., Hosoda, E., Ikegami, S., and Kishimoto, T. (2021). The Starfish Asterina pectinifera: Collection and Maintenance of Adults and Rearing and Metamorphosis of Larvae. Methods in Mol. Biol. "Developmental Biology of the Sea Urchin and Other Marine Invertebrates: Methods and Protocols, Second Edition" (eds. Stephen A. Stricker and David J. Carroll), vol. 2219, Chap. 3, in press, Springer Science+Business Media, New York.

20. Kishimoto, T.(2018). MPF-based meiotic cell cycle control: Half a century of lessons from starfish oocytes. Proc. Jpn. Acad., Ser. B, 94, 180-203 (doi: 10.2183/pjab.94.013).

19. Kubiak, J.Z., and Kishimoto, T.(2016). MPF, starfish oocyte and cell-free extract in the background – an interview with Takeo Kishimoto. Int. J. Dev. Biol., 60, 193-200 (Special issue edited by Jacek Z. Kubiak).

18. Kishimoto, T.(2015). Entry into mitosis: a solution to the decades-long enigma of MPF (review). Chromosoma, 124, 417-428 (DOI 10.1007/s00412-015-0508-y).

17. Okumura, E., Hara, M., and Kishimoto, T.(2014). Antibody inhibition of protein activity in starfish oocytes. In “Developmental Biology of the Sea Urchin and other Marine Invertebrates” (Carroll, D. and Stricker, S.A., eds.). Methods in Mol. Biol., vol. 1128, Chap. 21, pp. 311-330, Springer Science+Business Media, New York.

16. Kishimoto, T.(2011). A primer on meiotic resumption in starfish oocytes: The proposed signaling pathway triggered by maturation-inducing hormone (Short Note). Mol. Reprod. Dev.(FHL Special Issue), 78, 704-707.

15. Nishiyama, T., Tachibana, K., and Kishimoto, T.(2010). Cytostatic arrest: Post-ovulation arrest until fertilization in metazoan oocytes. In “Oogenesis: The Universal Process” (Verlhac, M.H. and Villeneuve, A., eds.), Chap. 14, pp. 357-384, Wiley-Blackwell, UK.

14. Kishimoto, T.(2005). Cell cycle unleashed (News and Views). Nature, 437, 963-965.

13. Kishimoto, T.(2005). In memory of Andre Picard: 1950-2004 (Obituary). Biol. Cell, 97, 349-350.

12. Kishimoto, T.(2004). More than G1 or G2 arrest: Useful starfish oocyte system for investigating skillful MAP kinase (Review). Biol. Cell, 96, 241-244.

11. Kishimoto, T.(2003). Cell cycle control during meiotic maturation. Curr. Opin. Cell Biol., 15, 654-663.

10. Kishimoto, T.(2000). Meiotic cell-cycle control. Human Frontier Science Program Workshop IX "Cell Division and the Replicon" (Fangman, W.L., Kishimoto, T., Kohiyama, M. and Coath, C., eds), pp.140-145. Human Frontier Science Program, Strasbourg.

9. Kishimoto, T.(1999). Activation of MPF at meiosis reinitiation in starfish oocytes (Review). Dev. Biol., 214, 1-8.

8. Kishimoto, T.(1999). Oocyte maturation and spawning in starfish. Encyclopedia of Reproduction(Knobil, E. and Neill, J.D., eds.), vol.3, pp.481-488. Academic Press, San Diego.

7. Kishimoto, T.(1998). Cell cycle arrest and release in starfish oocytes and eggs. Semin. Cell Dev. Biol., 9, 549-557.

6. Kishimoto, T.and Okumura, E. (1997). In vivo Regulation of the entry into M-phase: initial activation and nuclear translocation of cyclin B/Cdc2. Progress in Cell Cycle Res. (Meijer, L., Guidet, S. and Philippe, M., eds.), vol. 3, pp.241-249, Plenum Press, New York.

5. Kishimoto, T.(1996). Starfish maturation-promoting factor. Trends Biochem. Sci.,21, 35-37.

4. Kishimoto, T.(1994). Cell reproduction: induction of M-phase events by cyclin-dependent cdc2 kinase (Review). Int. J. Dev. Biol., 38, 185-191.

3. Kishimoto, T.(1988). Regulation of metaphase by a maturation-promoting factor (Review). Dev. Growth Differ., 30, 105-115.

2. Kishimoto, T.(1986). Maturation-promoting factor in starfish oocytes: Preliminary characterizaion and action on oocyte-follicle cell junctions. In "Advances in Invertebrate Reproduction"(M. Porchet, J. C. Andries and A. Dhainaut, eds.). vol. 4, pp.257-264. Elsevier Sci. Pub. BV, Amsterdam.

1. Kishimoto, T.(1986). Microinjection and cytoplasmic transfer in starfish oocytes. In "Echinoderm Gametes and Embryos" (T. E. Schroeder, ed.). Methods in Cell Biol., vol.27, pp.379-394. Academic Press, New York.


25. 岸本健雄.増井禎夫(1931-)—細胞周期研究をブレークさせた発生学者.生体の科学、70 (5)、384-385 (2019).

24. 馬渡駿介、岸本健雄.自然史標本の継承—人類の財産を失わないために今なすべきこと—.学術の動向、20 (5)、9 (2015).

23. 岸本健雄.細胞分裂制御におけるGreatwallキナーゼの新規機能.バイオサイエンスとインダスタトリー、71、536-537 (2013).

22. 岸本健雄.オーバービュー:細胞周期研究の歴史と生命現象解明への展開.「ヒトと医学のステージへ拡大する細胞周期2013:がん治療と生命現象の解明をめざして」(中山敬一編)、実験医学(増刊号)、31、144-153 (2013).

21. 立花和則・岸本健雄.第VII章-29.c-Mosによる卵子染色体半数化と単為発生の抑制.「卵子学」(森崇英編)pp.312-328、京都大学出版会 (2011).

20. 佐方功幸・稲垣昌樹・岸本健雄(編集).「細胞周期フロンティア」.共立出版.p.252 (2010).

19. 岸本健雄.特集「細胞周期研究の新たなステージ」(監修).細胞工学(1月号)、28、9-66 (2009).

18. 岸本健雄(分担編集、分担執筆).生化学辞典(第4版)、東京化学同人 (2007).

17. 岸本健雄.ヒトデ卵の成熟と減数分裂周期の制御機構——半世紀にわたる研究の展開.動物学会編纂「シリーズ21世紀の動物科学」第6巻「細胞の生物学」、pp.9-58、培風館 (2007).

16. 岸本健雄.細胞周期研究のビッグバン.「細胞周期集中マスター」(北川雅敏編)、pp.12-33、羊土社 (2006).

15. 竹内隆、岸本健雄(編集).「発生における細胞増殖制御」.シュプリンガーフェアラーク東京.p.198 (2004).

14. 岸本健雄.減数分裂周期の制御機構——世代の交代に際してゲノムの恒常性を維持するためには——.学術月報(日本学術振興会)、56、1253-1257 (2003).

13. 岸本健雄.シリーズ:検証・20世紀の生物科学「細胞周期」.遺伝、56(3)、77-87 (2002).

12. 岸本健雄.サイクリン-CDKとチェックポイント.日本生化学会・バイオサイエンスの新世紀 第6巻「細胞の誕生と死」(長田重一、山本雅編)共立出版 (2001).

11. 岸本健雄.細胞増殖と細胞周期.「現代生物科学」第8章(山田晃弘、中澤透編)放送大学 (2000).

10. 岸本健雄.評伝モラリスト生物学者.「続ロマンチックな科学者」(井川洋二編)羊土社 (2000).

9. 増井禎夫、岸本健雄.特別インタビュー「1998年ラスカー賞受賞 増井禎夫先生の研究者人生ぶらり40年」.細胞工学、18、1362-1371 (1999).

8. 岸本健雄(分担).細胞周期.「細胞機能と代謝マップ、II.細胞の動的機能」(日本生化学会編)東京化学同人 (1998).

7. 岸本健雄.酵母の細胞周期調節遺伝子cdc2 に相同な遺伝子がヒトにもある.英語論文セミナー「現代の細胞生物学」(丸山工作監修、馬渕一誠・山本正幸編)pp.104-111、講談社 (1996).

6. 岸本健雄、山下茂.細胞周期の分子生物学(監訳)(原著:A. Murray and T. Hunt, The Cell Cycle: an introduction, Oxford Univ. Press, 1993).メディカル・サイエンス・インターナショナル(東京)、p.248 (1995).

5. 岸本健雄.卵成熟とcdc2キナーゼ.新生化学実験講座 第14巻「発生・分化・老化」(日本生化学会編)pp.143-158 (1992).

4. 岸本健雄.MPF・cdc2キナーゼ・サイクリン—M期の制御と細胞周期の制御—.Annual Review細胞生物学1991(中外医学社)、217-235 (1991).

3. 大方香代子、岸本健雄.細胞周期を調節するメカニズムの解明(翻訳)(原題:A.W. Murray and M.W. Kirschner, What controls the cell cycle, Scientific American, March 1991).日経サイエンス、32-41 (1991、5月号).

2. 岸本健雄.卵の細胞周期を調節するしくみ.形態形成プログラム「発生・分化の遺伝子的背景」(江口吾朗、鈴木義昭、名取俊二編)pp.23-36、東京大学出版会(1990).

1. 岸本健雄.卵成熟促進因子(MPF)による細胞分裂の制御.生物物理、26、157-167 (1986).

岸本健雄 略歴(平成30年1月現在)

昭和42年4月 東京大学教養学部理科I類入学
昭和46年6月 東京大学理学部化学科卒業
昭和46年7月 東京大学大学院理学系研究科動物学専攻修士課程進学
昭和51年3月 同博士課程修了、理学博士(東京大学)
昭和51年4月 日本学術振興会奨励研究員
昭和53年1月 生物科学総合研究機構基礎生物学研究所 助手
昭和62年7月 岡崎国立共同研究機構基礎生物学研究所 助教授
昭和62年12月 東京工業大学理学部 教授
平成 2年6月 東京工業大学生命理工学部 教授
平成11年4月 東京工業大学大学院生命理工学研究科 教授
平成25年3月 (定年退職)東京工業大学 名誉教授
平成24年12月 お茶の水女子大学 客員教授 (現在に至る)
平成18年4月 日本学術振興会学術システム研究センター専門研究員 (平成21年3月迄)
平成18年10月 日本学術会議 連携会員 (平成23年9月迄)
平成23年10月 同 会員(第二部) (平成29年7月迄)
平成29年7月 同 連携会員 (現在に至る)
平成29年9月 一般社団法人国立沖縄自然史博物館設立準備委員会代表理事 (現在に至る)
日本動物学会賞(平成5年11月) 「卵細胞を用いた細胞複製機構の研究」
第10回比較腫瘍学常陸宮賞(平成17年5月) 「プロトオンコジンによる胚発生の制御」
チェコ科学アカデミー・メンデルメダル(平成22年6月) The Gregor Johann Mendel Honorary Medal for Merit in the Biological Sciences (The Academy of Sciences of the Czech Republic)