桜見出し

研究業績


英文原著論文 及び 総説


134. Search for the most ‘primitive’ membranes and their reinforcers. Nakatani, Y., Ribeiro, N., Streiff, S., Gotoh, M., Pozzi G., Désaubry, L., Milon, A. Orig. Life Evol. Biosph. in press.
133. Cyclic phosphatidic acid treatment suppress cuprizone-induced demyelination and motor dysfunction in mice. Yamamoto, S., Gotoh, M., Kawamura, Y., Yamashina, K., Yagishita, S., Awaji, T., Maruyama, K., Murakami-Murofushi, K., Yoshikawa, K. (2014) Eur. J. Pharmacol. 741:17-24.
132. Cyclic phosphatidic acid relieves osteoarthritis symptoms. Gotoh, M.†, Nagano A.†, Tsukahara R., Murofushi H., Murakami-Murofushi, K. †These authors equally contributed to this study. (2014) Mol. Pain 10:52.
131. Cyclic phosphatidic acid and lysophosphatidic acid induce hyaluronic acid synthesis via CREB transcription factor regulation in human skin fibroblasts. Maeda-Sano, K., Gotoh, M., Morohoshi, T., Someya, T., Murofushi, H., Murakami-Murofushi, K. (2014) Biochim. Biophys. Acta, Mol. Cell Biol. Lipids 1841:1256-1263.
130. Cholesterol glucosylation is catalyzed by transglucosylation reaction of β-glucosidase 1. Akiyama H., Kobayashi S., Hirabayashi Y., Murakami-Murofushi K. (2013)  Biochem. Biophys. Res. Commun. 441: 838-843.
129. The macroscopic structure of RADA16 peptide hydrogel stimulates monocyte/macrophage differentiation in HL60 cells via cholesterol synthesis. Kakiuchi Y., Hirohashi N., Murakami-Murofushi K. (2013) Biochem. Biophys. Res. Commun. 433:298-304.
128. “Physarolisin” in Handbook of Proteolytic Enzymes. Third Edition. Rawlings, N. D., Guy Salvesen, G. (eds.), Nishii, W., Murakami-Murofushi, K., Takanashi K. (2013) Academic Press, pp. 3347-3349.
127. Protection of neuroblastoma Neuro2A cells from hypoxia-induced apoptosis by cyclic phosphatidic acid (cPA). Gotoh, M., Sano-Maeda, K., Murofushi, H. Murakami-Murofushi, K. (2012) PLoS ONE 7(12) art. no. e51093.
126. Release of cyclic phosphatidic acid from gelatin-based hydrogels inhibit colon cancer cell growth and migration. Tsukahara, T., Murakami-Murofushi, K. (2012) Scientific Reports 2: art. no. 00687.
125. Pharmacological evaluation of a novel cyclic phosphatidic acid derivative 3-S-cyclic phosphatidic acid (3-S-cPA). Nozaki, E., Gotoh, M., Tanaka, R., Kato, M., Suzuki, T., Nakazaki, A., Hotta, H., Kobayashi, S., Murakami-Murofushi, K. (2012) Bioorg. Med. Chem.  20: 3196-3201.
124. Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis. Gotoh, M., Fujiwara, Y., Yue, J., Liu, J., Lee, S., Fells, J., Uchiyama, A., Murakami-Murofushi, K., Kennel, S., Wall, J., Patil, R., Gupte, R., Balazs, L., Miller, D.D., Tigyi, G.J. (2012) Biochem. Soc. Trans. 40: 31-36.
123. Efficient synthesis of 3-O-thia-cPA and preliminary analysis of its biological activity toward autotaxin. Tanaka, R., Kato, M., Suzuki, T., Nakazaki, A., Nozaki, E., Gotoh, M., Murakami-Murofushi, K., Kobayashi, S. (2011) Bioorg. Med. Chem. Lett. 21:4180-4182.
122. Comparison of inhibitory activities of stereo-isomers of cyclic phosphatidic acid (cPA) on autotaxin. Nozaki, E., Gotoh, M., Hanazawa, S., Mori, H., Kobayashi, S., Murakami-Murofushi, K. (2011) Cytologia 76: 73-80.
121. A possible mechanism of cholesteryl glucoside formation involved in heat shock response in the animal cell membrane. Akiyama, H., Hamada, T., Nagatsuka, Y., Kobayashi, S., Hirabayashi, Y., Murakami-Murofushi, K. (2011) Cytologia 76 :19-25.
120. DNA packaging proteins Glom and Glom2 coordinately organize the mitochondrial nucleoid of Physarum polycephalum. Itoh, K., Izumi, A., Mori, T., Dohmae, N., Yui, R., Maeda-Sano, K., Shirai, Y., Kanaoka, M. M., Kuroiwa, T., Higashiyama, T., Sugita, M., Murakami-Murofushi, K., Kawano, S., Sasaki, N. (2011) Mitochondrion 11:575-586.
119. Antinociceptive effect of cyclic phosphatidic acid and its derivative on animal models of acute and chronic pain. Kakiuchi, Y., Nagai, J., Gotoh, M., Hotta, H., Murofushi, H., Ogawa, T., Ueda, H., Murakami-Murofushi, K. (2011) Mol. Pain 7:33-43.
118. Novel sterol glucosyltransferase in the animal tissue and cultured cells: Evidence that glucosylceramide as glucose donor. Akiyama, H., Sasaki, N., Hanazawa, S., Gotoh, M., Kobayashi, S., Hirabayashi, Y., Murakami-Murofushi, K. (2011) Biochim. Biophys. Acta, Mol. Cell Biol. Lipids 1811:314-322.
117. Synthesis of enantiopure 2-Carba-cyclic phosphatidic acid and effects of its chirality on biological functions. Nozaki, E., Gotoh, M., Hotta, H., Hanazawa, S., Kobayashi, S., Murakami-Murofushi, K. (2011) Biochim. Biophys. Acta, Mol. Cell Biol. Lipids 1811:271-277.
116. Cyclic phosphatidic acid influences the expression and regulation of cyclic nucleotide phosphodiesterase 3B and lipolysis in 3T3-L1 cells. Tsukahara, T., Hanazawa, S., Murakami-Murofushi, K. (2011) Biochem. Biophys. Res. Commun. 404:109-114.
115. “Biomimetic synthesis and properties of polyprenoids” in On Biomimetics.  Pramatarova L. D. (ed.), Ribeiro N., Gotoh, M., Nakatani Y., Désaubry L., (2011) InTech, pp.195-212.
114. Transcellular invasion of MM1 rat ascites hepatoma cells requires matrix metalloproteinases derived from host mesothelium. Uchiyama, A., Arai, Y., Kobayashi, T., Tigyi, G., Murakami-Murofushi, K. (2010) Cytologia 75:267-272.
113. Lysophosphatidic acid-activated Cl- current activity in human systemic sclerosis skin fibroblasts Yin, Z., Carbone, L.D,, Gotoh, M., Postlethwaite, A,, Bolen, A.L., Tigyi, G.J., Murakami-Murofushi, K., Watsky, M.A. (2010) Rheumatology 49: 2290-2297.
112. Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid. Gupte, R., Siddam, A., Lu, Y., Li, W., Fujiwara, Y., Panupinthu, N., Pham, T.-C., Baker, D.L., Parrill, A. L., Gotoh, M., Murakami-Murofushi, K., Kobayashi, S., Mills, G.B., Tigyi, G., Miller, D.D. (2010) Bioorg. Med. Chem. Lett. 20:7525-7528.
111. Effects of cyclic phosphatidic acid on delayed neuronal death following transient ischemia in rat hippocampal CA1. Gotoh, M., Hotta, H., Murakami-Murofushi, K. (2010) Eur. J. Pharmacol. 649:206-209.
110. (S)-FTY720-Vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a panatagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity. Valentin, W.J., Kiss, G.N., Liu, J., Shuyu, E., Gotoh, M., Murakami-Murofushi, K., Pham, T.C., Baker, D.L., Parrill, A.L., Lu, X., Sun, C., Bittman, R., Pyne, N.J., Tigyi, G.(2010) Cell. Signal. 10:1543-1553.
109. Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells by inhibiting peroxisome proliferator-activated receptor γ. Tsukahara, T., Hanazawa, S., Kobayashi, T., Iwamoto, Y., Murakami-Murofushi, K. (2010) Prostaglandins Other Lipid Mediators 93:126-133.
108. Effect of endurance exercise training on oxidative stress in spontaneously hypertensive rats (SHR) after emergence of hypertension. Kimura, H., Kon, N., Furukawa, S., Mukaida, M., Yamakura, F., Matsumoto, K., Sone, H., Murakami-Murofushi, K. (2010) Clin. Exp. Hypertens. 32:407-415.
107. Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARγ by cyclic phosphatidic acid. Tsukahara, T., Tsukahara, R., Fujiwara, Y., Yue, J., Cheng, Y., Guo, H., Bolen, A., Zhang, C., Balazs, L., Re, F., Du, G., Frohman, M.A., Baker, D.L., Parrill, A.L., Uchiyama, A., Kobayashi, T., Murakami-Murofushi, K., Tigyi, G. (2010) Mol. Cell 39:421-432.
106. Enlargement of influenza virus hemagglutinin cytoplasmic tail by tagging with an enhanced green fluorescent protein interferes with hemagglutinin-mediated membrane fusion prior to the lipid-mixing step. Gotoh, M., Kotani, N., Takahashi, M., Okada, T., Ogawa, Y. (2010) Cytologia, 75: 435-442.
105. Cdc42/N-WASP and Rac1/WAVE2 required for LPA-induced migration of rat ascites hepatoma cells. Uchiyama, A., Tigyi, G., Murakami-Murofushi, K. (2010) Cytologia 75:195-201.
104. Inhibition of human tumor cell proliferation by the telomerase inhibitor TELIN. Kakiuchi, Y., Oyama, M., Nakatake, M., Okamoto, Y., Kai, H., Arima, H., Murofushi, H., Murakami-Murofushi, K. (2010) Cytologia 75:177-183.
103. Unique characteristics of radiation-induced apoptosis in the postnatally developing small intestine and colon of mice. Miyoshi-Imamura, T., Kakinuma, S., Kaminishi, M., Okamoto, M., Takabatake, T., Nishimura, Y., Imaoka, T., Nishimura, M., Murakami-Murofushi, K., Shimada, Y. (2010) Radiat. Res. 173:310-318.
102. Visualization of mitochondrial and apicoplast nucleoids in the human malaria parasite plasmodium falciparum by SYBR Green i and PicoGreen staining. Maeda-Sano, K., Sato, S., Ueda, T., Yui, R., Lto, K., Hata, M., Nakano, A., Kita, K., Murakami-Murofushi, K., Sasaki, N. (2009) Cytologia 74:449-455.
101. New protein Pmn34 with an exonuclease motif localizes in the mitochondrial nucleoid periphery of Physarum polycephalum. Itoh, K., Izumi, A., Mori, T., Dohmae, N., Yui, R., Maeda-Sano, K., Kanaoka, M.M., Kuroiwa, H., Kuroiwa, T., Higashiyama, T., Murakami-Murofushi, K., Kawano, S., Sasaki, N. (2009) Cytologia 74:401-407.
100. MOV10 as a novel telomerase-associated protein. Nakano, M., Kakiuchi, Y., Shimada, Y., Ohyama, M., Ogiwara, Y., Sasaki-Higashiyama, N., Yano, N., Ikeda, F., Yamada, E., Iwamatsu, A., Kobayashi, K., Nishiyama, K., Ichikawa, S., Kaji, K., Ide, T., Murofushi, H., Murakami-Murofushi, K. (2009) Biochem. Biophys. Res. Commun. 388:328-332.
99. The plasmodium HU homolog, which binds the plastid DNA sequence-independent manner, is essential for the parasite's survival. Sasaki, N., Hirai, M., Maeda, K., Yui, R., Itoh, K., Namiki, S., Morita, T., Hata, M., Murakami-Murofushi, K., Matsuoka, H., Kita, K., Sato, S. (2009) FEBS Lett. 583:1446-1450.
98. Early weaning induces anxiety and precocious myelination in the anterior part of the basolateral amygdala of male Balb/c mice. Ono, M., Kikusui, T., Sasaki, N., Ichikawa, M., Mori, Y., Murakami-Murofushi, K. (2008) Neuroscience 156:1103-1110.
97. Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway. Sakai, K., Yokote, H., Murakami-murofushi, K., Tamura, T., Saijo, N., Nishio, K. (2007) Cancer Sci. 98:1498-1503.
96. STAT3 and PKC differentially regulate telomerase activity during megakaryocytic differentiation of K562 cells. Nakatake, M., Kakiuchi, Y., Sasaki, N., Murakami-Murofushi, K., Yamada, O. (2007) Cell Cycle 6:1496-1501.
95. Inhibition of transcellular tumor cell migration and metastasis by novel carba-derivatives of cyclic phosphatidic acid. Uchiyama, A., Mukai, M., Fujiwara, Y., Kobayashi, S., Kawai, N., Murofushi, H., Inoue, M., Enoki, S., Tanaka, Y., Niki, T., Kobayashi, T., Tigyi, G., Murakami-Murofushi, K. (2007) Biochim. Biophys. Acta, Mol. Cell Biol. Lipids 1771:103-112.
94. Possible molecular evolution of biomembranes: from single-chain to double-chain lipids. Gotoh, M., Sugawara, A., Akiyoshi, K., Matsumoto, I., Ourisson, G., Nakatani, Y. (2007) Chem. Biodiversity 4: 837-848.
93. Reinforcing effect of bi- and tri-cyclopolyprenols on “primitive” membranes made of polyprenyl phosphates. Ribeiro, N., Streiff, S., Heissler, D., Elhabiri, M., Albrecht-Gary, A.M., Atsumi, M., Gotoh, M., Désaubry, L., Nakatani, Y., Ourisson, G. (2007) Tetrahedron, 63:3395-3407.
92. Cyclic phosphatidic acid is produced by autotaxin in blood. Tsuda, S., Okudaira, S., Moriya-Ito, K., Shimamoto, C., Tanaka, M., Aoki, J., Arai, H., Murakami-Murofushi, K., Kobayashi, T. (2006) J. Biol. Chem. 281:26081-26088.
91. Cyclic phosphatidic acid stimulates respiration without producing vasopressor or tachycardiac effects in rats. Hotta, H., Kagitani, F., Murakami-Murofushi, K. (2006), Eur. J. Pharmacol. 543:27-31.
90. Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis. Baker, D.L., Fujiwara, Y., Pigg, K.R., Tsukahara, R., Kobayashi, S., Murofushi, H., Uchiyama, A., Murakami-Murofushi, K., Koh, E., Bandle, R.W., Byun,H.-S., Fan, D., Murph, M., Mills, G.B., Tigyi, G. (2006) J. Biol. Chem. 281:22786-22793.
89. In-frame deletion in the EGF receptor alters kinase inhibition by gefitinib. Sakai, K., Yokote, H., Murakami-Murofushi, K., Tamura, T., Saijo, N., Nishio, K. (2006) Biochem. J. 397:537-543.
88. Regulation of levels of actin threonine phosphorylation during life cycle of Physarum polycephalum. Shirai, Y., Sasaki, N., Kishi, Y., Izumi, A., Itoh, K., Sameshima, M., Kobayashi, T., Murakami-Murofushi, K. (2006) Cell Motil. Cytoskel. 63:77-87.
87. Dimeraization and the signal transduction pathway of a small in-frame deletion in the epidermal growth factor receptor. Sakai, K., Arao, T., Shimoyama, T., Murofushi, K., Sekijima, M., Kaji, N., Tamura, T., Saijo, N., Nishio, K. (2006) FASEB J. 20:311-313.
86. Membrane properties of branched polyprenyl phosphates, postulated as primitive membrane constituents.  Gotoh, M., Miki, A., Nagano, H., Ribeiro, N., Elhabiri, M., Gumienna-Kontecka, E., Albrecht-Gary, A.-M., Schmutz, M., Ourisson, G., Nakatani, Y. (2006) Chem. Biodiversity, 3:434-455.
85. A novel type of membrane based on cholesteryl phosphocholine, cholesteryl phosphate or sitosteryl phosphate and dimyristoylglycerol.  Gotoh, M., Ribeiro, N., Michels, B., Elhabiri, M., Albrecht-Gary, A.-M., Yamashita, J., Hato, M., Ourisson, G., Nakatani, Y. (2006) Chem. Biodiversity, 3:198-209.
84. Involvement of CD45 in central nervous system myelination. Nakahara J., Seiwa C., Tan-Takeuchi K., Gotoh M., Kishihara K., Ogawa M., Asou H., Aiso S. (2005) Neuroscience Lett., 379:116-121.
83. Annexins I and IV inhibit Staphylococcus aureus attachment to human macrophages. Gotoh, M., Takamoto, Y., Kurosaka, K., Masuda, J., Ida, M., Satoh, A., Takayama, E., Kojima-Aikawa, K., Kobayashi, Y., Matsumoto I. (2005) Immunology Lett.,98:297-302.
82. Identification of residues responsible for ligand recognition and regioisomeric selectivity of lysophosphatidic acid receptors expressed in mammalian cells. Fujiwara, Y., Sardar, V., Tokumura, A., Baker, D., Murakami-Murofushi, K., Parrill, A., Tigyi, G. (2005) J. Biol. Chem. 280:5038-35050.
81. A novel pyrazolone, 4,4-dichloro-1-(2,4-dichlorophenyl)-3-methyl-5- pyrazolone, as a potent catalytic inhibitor of human telomerase. Kakiuchi, Y., Sasaki, N., Satoh-Masuoka, M., Murofushi, H., Murakami-Murofushi, K. (2004) Biochem. Biophys. Res. Commun. 320:1351-1358.
80. Attenuation by cyclic phosphatidic acid of peritoneal metastasis of azoxymethane-induced intestinal cancers in Wistar rats. Ishihara, R., Tatsuta, M., Iishi, H., Baba, M., Uedo, N., Higashino, K., Mukai, M., Ishiguro, S., Kobayashi, S., Murakami-Murofushi, K. (2004) Int. J. Cancer 110:188-193.
79. Transient posttranslational up-regulation of telomerase activity during megakaryocytic differentiation of K562 cells. Nakatake, M., Sasaki, N., Murakami-Murofushi, K., Yamada, O.  (2004) Biochem. Biophys. Res. Commun. 314:1080-1085.
78. “Physarolisin” in Handbook of Proteolytic Enzymes. Second Edition. Barrett, A. J., Rawlings, N. D., Woessner, J. F. (eds.), Murakami-Murofushi, K., Nishii, W., Takanashi K. (2004) Elsevier Academic Press, pp. 1891-1893.
77. Glom is a novel mitochondrial DNA packaging protein in Physarum polycephalum and causes intense chromatin condensation without suppressing DNA functions. Sasaki, N., Kuroiwa, H., Nishitani, C., Takano, H., Higashiyama, T., Kobayashi, T., Shirai, Y., Sakai, A., Kawano, S., Murakami-Murofushi, K., Kuroiwa, T. (2003) Mol. Biol. Cell 14:4758-4769.
76. Cyclic phosphatidic acid elicits neurotrophin-like actions in embryonic hippocampal neurons. Fujiwara, Y., Sebök, A., Meakin, S., Kobayashi, T., Murakami-Murofushi, K., Tigyi, G. (2003) J. Neurochem. 87:1272-1283.
75. Cholesteryl glucoside-induced protection against gastric ulcer. Kunimoto, S., Murofushi, W., Yamatsu, I., Hasegawa, Y., Sasaki, N., Kobayashi, S., Kobayashi, T., Murofushi, H., Murakami-Murofushi, K. (2003) Cell Struct. Funct. 28:179-186.
74. Cyclic phosphatidic acid inhibits RhoA-mediated autophosphorylation of FAK at Tyr-397 and subsequent tumor-cell invasion. Mukai, M., Iwasaki, T., Tatsuta, M., Togawa, A., Nakamura, H., Murakami-Murofushi, K., Kobayashi, S., Imamura, F., Inoue, M. (2003) Int. J.  Oncol. 22:1247-1256.
73. Structural and enzymatic characterization of physarolisin (formerly physaropepsin) proves that it is a unique serine-carboxyl proteinase. Nishii, W., Ueki, T., Miyashita, R., Kojima, M., Kim, Y.-T., Sasaki, N., Murakami-Murofushi, K., Takahashi, K. (2003) Biochem. Biophys. Res. Commun. 301:1023-1029.
72. Effect of a traditional Chinese herbal medicine, Ren-Shen-Yang-Rong-Tang (Japanese name: Ninjin-Youei-To), on oligodendrocyte precursor cells from aged-rat brain. Kobayashi J., Seiwa C., Sakai T., Gotoh M., Komatsu Y., Yamamoto M., Fukutake M., Matsuno K., Sakurai Y., Kawano Y., Asou H. (2003) Int. Immunopharmacol., 3:1027-1039.
71. Signaling via immunoglobulin Fc receptors induces oligodendrocyte precursor cell differentiation. Nakahara J., Tan-Takeuchi K., Seiwa C., Gotoh M., Kaifu T., Ujike A., Inui M., Yagi T., Ogawa M., Aiso S., Takai T., Asou H. (2003) Developmental Cell, 4:841-852.
70. A novel membrane protein, Ros3p, is required for phospholipid translocation across the plasma membrane in Saccharomyces cerevisiae. Kato, U., Emoto, K., Fredriksson, C., Nakamura, H., Ohta, A., Kobayashi, T., Murakami-Murofushi, K., Kobayashi, T., Umeda, M. (2002) J. Biol. Chem. 277:37855-37862.
69. Steryl glucoside is a lipid mediator in stress-responsive signal transduction. Kunimoto, S., Murofushi, W., Kai, H., Ishida, Y., Uchiyama, A., Kobayashi, T., Kobayashi, S., Murofushi, H., Murakami-Murofushi, K. (2002) Cell Struct. Funct. 27:157-162.
68. Biological functions of a novel lipid mediator, cyclic phosphatidic acid. Murakami-Murofushi, K., Uchiyama, A., Fujiwara, Y., Kobayashi, T., Kobayashi, S., Mukai, M., Murofushi, H., Tigyi, G. (2002) Biochim. Biophys. Acta, Mol. Cell Biol. Lipids 1582:1-7.
67. Biological functions of a novel lipid mediator, cyclic phosphatidic acid (cPA). Kobayashi, T., Murakami-Murofushi, K. (2002) Nat. Sci. Rep., Ochanomizu Univ. 53:45-48.
66. Bioactions and synthesis of a novel lipid mediator, cyclic phosphatidic acid. Kobayashi, T., Murakami-Murofushi, K. (2001) World Rev. Nutr. Diet. 88:228-232.
65. Altered expression of HES-1, BETA2/NeuroD, and PDX-1 is involved in impaired insulin synthesis induced by glucocorticoids in HIT-T15 cells. Shinozuka, Y., Okada, M., Oki, T., Sagane, K., Mizui, Y., Tanaka, I., Katayama, K., Murakami-Murofushi, K. (2001) Biochem. Biophys. Res. Commun. 287:229-235.
64. Determinants of receptor subtype specificity in the LPA-like lipid mediator family. Tigyi, G., Fisher, D.J., Lilion, K., Guo, Z., Virag, T., Sun, G., Miller, D.D., Murakami-Murofushi, K., Kobayashi, S., Erickson, J.R. (2000) Adv. Exp. Med. Biol. 469:245-251.
63. Characterization of endogenous and heterologously expressed LPA receptor subtypes. Fischer, D.J., Murakami-Murofushi, K., Tigyi, G. (2000) Ann. NY Acad. Sci. 905:287-289.
62. A novel lipid mediator, cyclic phosphatidic acid (cPA), and its biological functions. Murakami-Murofushi, K., Mukai, M., Kobayashi, S., Kobayashi, T., Tigyi, G., Murofushi, H.  (2000) Ann. NY Acad. Sci. 905:319-321.
61. Expression of cholesteryl glucoside by heat shock in human fibroblasts. Kunimoto, S., Kobayashi, T., Kobayashi, S., Murakami-Murofushi, K. (2000) Cell Stress Chaperon. 5:3-7.
60. Existence of a bioactive lipid, cyclic phosphatidic acid, bound to human serum albumin. Kobayashi, T., Tanaka-Ishii, R., Taguchi, R., Ikezawa, H., Murakami-Murofushi, K. (1999) Life Sci. 65:2185-2191.
59. Molecular cloning and characterization of a novel human G-protein- coupled receptor, EDG7, for lysophosphatidic acid. Bandoh, K., Aoki, J., Hosono, H., Kobayashi, S., Kobayashi, T., Murakami-Murofushi, K., Tsujimoto, M., Arai, H., Inoue, K. (1999) J. Biol. Chem. 274:27776-27785.
58. Hyperosmotic stress-induced reorganization of actin bundles in Dictyostelium cells over-expressing cofilin. Aizawa, H., Katadae, M., Maruya, M., Sameshima, M., Murakami-Murofushi, K., Yahara, I. (1999) Genes Cells 4:311-324.
57. Inhibition of tumor invasion and metastasis by a novel lysophosphatidic acid (cyclic LPA). Mukai, M., Imamura, F., Ayaki, M., Shinkai, K., Iwasaki, T., Murakami-Murofushi, K., Murofushi, H., Kobayashi, S., Yamamoto, T., Nakamura, H., Akedo, H. (1999) Int. J. Cancer 81:918-922.
56. Naturally occurring analogs of lysophosphatidic acid elicit different cellular responses through selective activation of multiple receptor subtypes. Fischer, D.J., Liliom, K., Guo, Z., Nusser, N., Vira?g, T., Murakami-Murofushi, K., Kobayashi, S., Erickson, J.R., Sun, G., Miller, D.D., Tigyi, G. (1998) Mol. Pharmacol. 54:979-988.
55. Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination. Furuse, M., Nagase, Y., Tsubouchi, H., Murakami-Murofushi, K., Shibata, T., Ohta, K. (1998) EMBO J. 17: 6412-6425.
54. A novel 66-kDa stress protein, p66, associated with the process of cyst formation of Physarum polycephalum is a Physarum homologue of a yeast actin-interacting protein, AIP1. Matsumoto, S., Ogawa, M., Kasakura, T., Shimada, Y., Mitsui, M., Maruya, M., Isohata, M., Yahara, I., Murakami-Murofushi, K. (1998) J. Biochem. 124:326-331.
53. Examination of the correlation between DNA-dependent protein kinase and telomerase activity. Ikeda, F., Matsumoto, Y., Suzuki, N., Murakami-Murofushi, K. (1998) Nat. Sci. Rep., Ochanomizu Univ. 49:7-12.
52. Expression of telomerase activity associated with transformation of human fibroblasts. Nakano, M., Shimada, Y., Kobayashi, T., Murakami-Murofushi, K. (1998) Nat. Sci. Rep., Ochanomizu Univ. 48:39-44.
51. Stimulation of Gq protein-coupled signal transduction by cyclic phosphatidic acid (cPA) and activation of protein kinase C in vitro. Murakami-Murofushi, K., Uchiyama, N., Kobayashi, T., Murofushi, H. (1998) Nat. Sci. Rep., Ochanomizu Univ. 48:29-38.
50. Response of a true slime mold, Physarum polycephalum, to salt stress II : The effects of the inhibitors for RNA and protein syntheses on stress-induced microcyst formation. Nishikawa, K., Uchiyama, N., Murakami-Murofushi, K., Shimizu, S. (1998) Nat. Sci. Rep., Ochanomizu Univ. 48:23-27.
49. Cell cycle-dependent activation of telomerase in naturally synchronized culture of a true slime mold, Physarum polycephalum. Shimada, Y., Nakano, M., Kanda, N., Murakami-Murofushi, K., Kim, J.K., Ide, T., Murofushi, H. (1997) Biochem. Biophys. Res. Commun. 232:492-496.
48. Heat stress induces a glycosylation of membrane sterol in myxoamoebae of a true slime mold, Physarum polycephalum. Murakami-Murofushi, K., Nishikawa, K., Hirakawa, E., Murofushi, H. (1997) J. Biol. Chem. 272:486-489.
47. Activation of a Ca2+-dependent protein kinase in response to heat shock in the myxoamoebae of a true slime mold, Physarum polycephalum. Maruya, M., Mitsui, M., Murakami-Murofushi, K. (1996) Cell Struct. Funct. 21:533-538.
46. Xenopus oocytes express multiple receptors for LPA-like lipid mediators. Liliom, K., Murakami-Murofushi, K., Kobayashi, S., Murofushi, H., Tigyi, G. (1996) Am. J. Physiol.-Cell Physiol. 270:C772-C777.
45. Telomere and telomerase in human leukocytes and immortal cell lines. Shimada, Y., Nakano, M., Murakami- Murofushi, K. (1996) Nat. Sci. Rep., Ochanomizu Univ. 47:35-43.
44. Response of a true slime mold, Physarum polycephalum, to salt stress. Uchiyama, N., Murakami-Murofushi, K. (1996) Nat. Sci. Rep., Ochanomizu Univ. 47:29-34.
43. Selective inhibition of DNA polymerase-α: Family with chemically synthesized derivatives of PHYLPA, a unique Physarum lysophosphatidic acid. Murakami-Murofushi, K., Kobayashi, S., Onimura, K., Matsumoto, M., Shioda, M., Yoshida, S., Shoji, M., Murofushi, H. (1995) Biochim. Biophys. Acta, Lipid. Lipid Met. 1258:57-60.
42. Reduced fidelity of DNA synthesis in cell extracts from chemically induced primary thymic lymphomas of mice. Kubota, Y., Murakami-Murofushi, K., Shimada, Y., Ogiu, T., Oikawa, T. (1995) Cancer Res. 55:3777-3780.
41. Chinese hamster ovary cells expressing a novel type of acetylated low density lipoprotein receptor. Isolation and characterization. Fukasawa, M., Hirota, K., Adachi, H., Mimura, K., Murakami-Murofushi, K., Tsujimoto, M., Arai, H., Inoue, K. (1995) J. Biol. Chem. 270:1921-1927.
40. A novel intracellular acid proteinase from the plasmodia of a true slime mold, Physarum polycephalum. Murakami-Murofushi, K., Takahashi, T., Murofushi, H., Takahashi, K. (1995) Adv. Exp. Med. Biol. 362:565-568.
39. Side-chain structure is critical for the transport of sterols from lysosomes to cytoplasm. Sato, Y., Nishikawa, K., Aikawa, K., Mimura, K., Murakami-Murofushi, K., Arai, H., Inoue, K. (1995) Biochim. Biophys. Acta, Lipid. Lipid Met. 1257:38-46.
38. Purification and characterization of an acid protease from myxoamoebae of a true slime mold, Physarum polycephalum. Minowa-Sonobe, Y., Shimada, Y., Murakami- Murofushi, K. (1994) Nat. Sci. Rep., Ochanomizu Univ. 45:67-78.
37. Characterization of nuclear, and nuclear matrix-bound DNA polymerases of normal rat liver. Uchiyama, N., Kohyama, N., Shimada, Y., Murakami-Murofushi, K. (1994) Nat. Sci. Rep., Ochanomizu Univ. 45:79-83.
36. Modulation of DNA synthesis by microtubule-associated protein 2 in the nuclear matrix isolated from Physarum polycephalum. Shioda, M., Okuhara, K., Murakami-Murofushi, K., Murofushi, H. (1993) Biochem. Mol. Biol. Int. 31:905-910.
35. Inhibition of cell proliferation by a unique lysophosphatidic acid, PHYLPA isolated from Physarum polycephalum: Signaling events of antiproliferative action by PHYLPA. Murakami-Murofushi, K., Kaji, K., Kano, K., Fukuda, M., Shioda, M., Murofushi, H. (1993) Cell Struct. Funct. 18:363-370.
34. Synthesis of 1-O-acylglycerol 2,3-cyclic phosphate: Determination of the absolute structure of PHYLPA, a specific inhibitor of DNA polymerase α. Kobayashi, S., Tokunoh, R., Shibasaki, M., Shinagawa, R., Murakami-Murofushi, K. (1993) Tetrahedron Lett. 34:4047-4050.
33. Isolation of a new species of Physarum lysophosphatidic acid, PHYLPA, and its effect on DNA polymerase activity. Takahashi, Y., Shimada, Y., Shioda, M., Yoshida, S., Murofushi, H., Murakami-Murofushi, K. (1993) Cell Struct. Funct. 18:135-138.
32. Initiation of DNA synthesis in a high molecular weight fraction of Xenopus egg extract. Okuhara, K., Shioda, M., Shiokawa, K., Murakami-Murofushi, K., Seyama, Y., Murofushi, H. (1993) Cell Biol. Int. l 17:275-282.
31. Expression of a 66-kD heat shock protein associated with the process of cyst formation of a true slime mold, Physarum polycephalum. Shimada, Y., Kasakura, T., Yokota, M., Miyata, Y., Murofushi, H., Sakai, H., Yahara, I., Murakami-Murofushi, K. (1992) Cell Struct. Funct. 17:301-309.
30. Inhibition of eukaryotic DNA polymerase α with a novel lysophosphatidic acid (PHYLPA) isolated from myxoamoebae of Physarum polycephalum. Murakami-Murofushi, K., Shioda, M., Kaji, K., Yoshida, S., Murofushi, H. (1992) J. Biol. Chem. 267:21512-21517.
29. Fatty acid species of bio-active lysophosphatidic acid from haploid myxoamoebae of Physarum Polycephalum. Takahashi, Y., Shimada, Y., Murakami- Murofushi, K. (1992) Nat. Sci. Rep., Ochanomizu Univ. 43:97-102.
28. Stimulation of DNA polymerase α activity by microtubule-associated proteins. Shioda, M., Okuhara, K., Murofushi, H., Mori, A., Sakai, H., Murakami-Murofushi, K., Suzuki, M., Yoshida, S. (1991) Biochemistry 30:11403-11412.
27. A novel purification method of sterols and steryl glucoside from plasmodia of a true slime mold, Physarum Polycephalum. Mimura, K., Murakami-Murofushi, K., Ohta, J. (1991) Nat. Sci. Rep., Ochanomizu Univ. 42:49-56.
26. Extracellular polysaccharide from a true slime mold, Physarum Polycephalum. Polymerization and auto-degradation associated with cell growth, and its inhibitory activity on eukaryotic DNA polymerase α. Shimada, Y., Murakami-Murofushi, K., Shioda, M., Ohta, J. (1991) Nat. Sci. Rep., Ochanomizu Univ. 42:39-47.
25. Existence of Poriferasterol Monoglucoside and UDP-glucose: Poriferasterol Glucosyltransferase in Haploid Myxoamoebae of Mating-less Mutant, Colonia Strain, of Physarum Polycephalum. Murakami-Murofushi, K., Kamiya, Y., Mimura, K., Ohta, J. (1990) Proc. Jpn. Acad. B, 66:197-202.
24. Purification and characterization of a novel intracellular acid proteinase from the plasmodia of a true slime mold, Physarum polycephalum. Murakami-Murofushi, K., Takahashi, T., Minowa, Y., Iino, S., Takeuchi, T., Kitagaki-Ogawa, H., Murofushi, H., Takahashi, K. (1990) J. Biol. Chem. 265:19898-19903.
23. Changes in phospholipid composition and phospholipase D activity during the differentiation of Physarum polycephalum. Minowa, A., Kobayashi, T., Shimada, Y., Maeda, H., Murakami-Murofushi, K., Ohta, J., Inoue, K. (1990) Biochim. Biophys. Acta, Lipid. Lipid Met. 1043:129-133.
22. DNA synthesis by the isolated nuclear matrix from synchronized plasmodia of Physarum polycephalum. Shioda, M., Matsuzawa, Y., Murakami-Murofushi, K., Ohta, J. (1989) Biochim. Biophys. Acta, Gene Struct. Expr. 1007:254-263.
21. Changes in activity and subcellular localization of alpha-like DNA polymerase during cell cycle of Physarum polycephalum. Shioda, M., Murakami-Murofushi, K. (1989) Biochem. Int. 18:581-588.
20. Expression of UDP-glucose:poriferasterol glucosyltransferase in the process of differentiation of a true slime mold, Physarum polycephalum. Murakami-Murofushi, K., Ohta, J. (1989) Biochim. Biophys. Acta, Gen. Subj. 992:412-415.
19. Microtubule-associated protein-2 stimulates DNA synthesis catalyzed by the nuclear matrix. Shioda, M., Murofushi, H., Murakami-Murofushi, K., Sakai, H. (1989) Biochem. Biophys. Res. Commun. 159:834-841.
18. “Physaropepsin” in Handbook of Proteolytic Enzymes. Barrett, A. J., Rawlings, N. D., Woessner, J. F. (eds.), Murakami-Murofushi, K. (1998) Academic Press, pp. 870-872.
17. Sterol contents of haploid myxoamoebae of Physarum polycephalum. Comparison with those of diploid plasmodia. Murakami-Murofushi, K., Nakamura, K., Ohta, J., Yokota, T. (1987) Cell Struct. Funct. 12:519-524.
16. DNA synthesis in isolated nuclei from synchronized plasmodia of Physarum polycephalum. Matsuzawa, Y., Murakami-Murofushi, K., Ohta, J., Shioda, M. (1987) Cell Struct. Funct. 12:243-250.
15. Expression of poriferasterol monoglucoside associated with differentiation of Physarum polycephalum. Murakami-Murofushi, K., Nakamura, K., Ohta, J., Suzuki, M., Suzuki, A., Murofushi, H., Yokota, T. (1987) J. Biol. Chem. 262:16719-16723.
14. Selective inhibition of DNA polymerase α by a polysaccharide purified from slime of Physarum polycephalum . Shioda, M., Murakami-Murofushi, K. (1987) Biochem. Biophys. Res. Commun. 146: 61-66.
13. Mannosyl glycoprotein(s) function in the conjugation of haploid amoebae of Physarum polycephalum . Murakami-Murofushi, K., Minowa, Y., Yamada, R., Ohta, J. (1986) Cell Struct. Funct. 11:219-225.
12. Visualization method for sulfolipids and its application to the determination of nanomole quantities of lipid sulfur. Murakami-Murofushi, K., Nakamura, K., Ishizuka, I., Ohta, J. (1985) Anal. Biochem. 149:480-483.
11. A novel acid protease from haploid amoebae of Physarum polycephalum, and its changes during mating and subsequent differentiation into diploid plasmodia. Murakami-Murofushi, K., Hiratsuka, A., Ohta, J. (1984) Cell Struct. Funct. 9:311-315.
10. A novel trisialosyl ganglioside, IV3α(NeuAc)3nLcOse4Cer, from Hog kidney cortex1. Murakami-murofushi, K., Tadano, K., Ishizuka, I. (1983) J. Biochem. 93:621-629.
9. “Isolation of Argininosuccinase from Bovine Brain: Catalytic, Physical, and Chemical Properties Compared to Liver and Kidney Enzymes” In Urea cycle Diseases (Advances in Experimental Medicine and Biology), Murakami- Murofushi, K., Ratner, S. (1982) Springer, pp.277-289.
8. A trisialosyl ganglioside GT3 of hog kidney. Structure and biosynthesis in vitro. Murakami-murofushi, K., Tadano, K., Koyama, I., Ishizuka, I. (1981) J. Biochem. 90:1817-1820.
7. A new radiochemical assay for argininosuccinase with purified [14C]argininosuccinate. Ratner, S., Murakami-Murofushi, K. (1980) Anal. Biochem. 106:134-147.
6. Argininosuccinase from bovine brain: Isolation and comparison of catalytic, physical, and chemical properties with the enzymes from liver and kidney. Murakami-Murofushi, K., Ratner, S. (1979) Anal. Biochem. 95:139-155.
5. Effect of colchicine on the mitosis of Physarum polycephalam. Hagino, K., Murakami, K., Ohta, J. (1978) Plant Cell Physiol. 19:711-715.
4. Stimulation of sea urchin DNA polymerase by protein factors. II. Formation of active complex in DNA polymerase reaction. Murakami-Murofushi, K., Mano, Y. (1977) Biochim. Biophys. Acta 475:254-266.
3. A cytoplasmic inhibitor of DNA polymerase from the plasmodia of Physarum polycephalum. Murakami Murofushi, K., Nagano, H., Mano, Y. (1976) J. Biochem. 80:735-741.
2. Stimulation of sea urchin DNA polymerase by protein factors. Murakami, K., Mano, Y. (1973) Biochem. Biophys. Res. Commun. 55:1125-1133.
1. Cytoplasmic control of mitosis in true slime mold, Physarum polycephalum. Murakami, K., Ohta, J. (1971) Plant Cell Physiol. 12:797-801.

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和文総説


13. 環状ホスファチジン酸に基づく安全で効果的な疼痛 治療薬の開発  室伏きみ子、後藤真里 (2013) 化学工業 64:6-11.
12. 脂質メディエーター・環状ホスファチジン酸(cPA)の痛み抑制効果とその医療応用への展望   後藤真里、室伏きみ子 (2012) バイオインダストリー (シーエムシー出版) 2:46-52.
11. 環状ホスファチジン酸を利用したアンチエイジング化粧品の開発 室伏きみ子(2011)バイオサイエンスとインダスト リー 69:44-45.
10. リン脂質メディエーター・環状ホスファチジン酸(cPA)に基づくバイオ化粧品の開発 (特集 アカデミア発バイオ化粧品素材の開発) 室伏きみ子(2010)バイオインダストリー(シーエムシー出版)27:7-12.
9. ストレス応答におけるステリルグルコシドのはたらき―脂質メディエーターとその応用(2) 室伏きみ子 (2009)メディカルバイオ (オーム社)6:58-65.
8. 環状ホスファチジン酸をめぐる話題―脂質メディエーターとその応用(1) 室伏きみ子 (2009)メディカルバイオ (オーム社)6:81-87.
7. ストレス応答性シグナル伝達におけるステリルグルコシドの役割 室伏きみ子(2008)膜(日本膜学会)33:273- 279.
6. 環状ホスファチジン酸とその誘導体による癌の浸潤・転移の抑制 (特集ユニークな創薬ターゲット分子--夢の薬に向かって) --(癌治療のための創薬ターゲット分子) 内山綾子、室伏きみ子(2003)医学のあゆみ(医歯薬出版)207:19-22.
5. 細胞分化・ストレス応答とステリルグルコシド 室伏きみ子、小林哲幸(1999)蛋白質核酸酵(共立出版)44: 1111-1117.
4. リゾリン脂質メディエーターとしてのリゾホスファチジン酸と環状ホスファチジン酸の存在、代謝および生理機能 小林哲 幸、室伏きみ子(1999)蛋白質核酸酵素(共立出版)44:1118-1125.
3. 粘菌における形態変化とストレス蛋白質(ストレス蛋白質<特集>) 室伏きみ子 (1995)生体の科学 46:352-355.
2. 細胞増殖抑制物質の開発 -新規リゾホスファチジン酸(PHYLPA)による細胞増殖の制御- 室伏きみ子、小林進 (1994) BIO INDUSTRY 11:484-496.
1. リゾホスファチジン酸による細胞増殖の制御 室伏きみ子(1993)蛋白質核酸酵素(共立出版)38:1396- 1401.

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特許


19. 環状ホスファチジン酸ナトリウムの製造 方法及び組成物
特  許  出  願: 2012-117412 (2012/05/23)
特  許  公  開: 2013-013404 (2013/01/24)
発    明     者: 室伏きみ子、今村 茂行
出    願     人: SANSHO株式会社
18. アトピー性皮膚炎治療剤
特  許  出  願: 2010-198475 (2010/09/06)
特  許  公  開: 2012-056853 (2012/03/22)
発     明    者: 室伏きみ子、諸星俊郎、藤原達郎、柏木沙予、桑原亜希子、須田一真
出     願    人: SANSHO株式会社
17. 環状ホスファチジン酸の製造方法
特  許  出  願: 2010-080964 (2010/03/31)
特  許  公  開: 2011-211921 (2011/10/27)
発     明    者: 室伏きみ子、今村 茂行
出     願    人: SANSHO株式会社
16. 神経細胞死抑制剤
特  許  出  願: 2011-543320 (2009-268225) (2009/11/26)
国際出願番号: PCT/JP2010/071127 (2010/11/26)
国際公開番号: W02011/065480 (2011/6/3)
発     明    者: 室伏きみ子、金敷晴美、後藤真里、小林進、室伏擴
出     願    人: 国立大学法人お茶の水女子大学、SANSHO株式会社
15. P19CL6のクローン細胞と心筋細胞 への分化誘導方法
特  許  出  願: 2009-060575 (2009/03/13)
特  許  公  開: 2010-213576 (2010/09/30)
発     明    者: 小川和重、ミュラー樹、室伏きみ子
出     願    人: 公立大学法人大阪府立大学
14. アトピー性皮膚炎治療剤
特  許  出  願: 2009-050194 (2009/03/04)
特  許  公  開: 2010-202585 (2010/09/16)
発     明    者: 室伏きみ子、諸星俊郎、藤原達郎
出     願    人: SANSHO株式会社
13. 環状ホスファチジン酸誘導体を含む鎮痛剤
特許第5077893号 (2012/09/07)
特  許  出  願: 2008-552022(2007/12/25)
特  許  公  開: 再公表08-081580(2010/04/30)
国際出願番号: JP2007001463
国際公開番号: WO08081580 (2008/07/10)
発     明    者: 室伏きみ子、金敷晴美
出     願    人: 国立大学法人お茶の水女子大学
12. ヒアルロン酸産生能増強剤およびその用途
特許第4876334号 (2011/12/09)
特  許  出  願: 2001-171689(2001/06/06)
特  許  公  開: 2002-363081(2002/12/18)
発     明    者: 田中信治、室伏きみ子、小林哲幸
出     願    人: 日本油脂株式会社
11. 環状ホスファチジン酸誘導体を含む神経細胞の生存促進剤
特許第4836345号 (2011/10/07)
特  許  出  願: 2001-115925 (2001/04/13)
特  許  公  開: 2002-308778(2002/10/23)
発     明    者: 室伏きみ子、ゲイバー・ティギー
出     願    人: 室伏きみ子
10. 環状ホスファチジン酸誘導体を含むグリア細胞の増殖、分化及び/又は生存の促進のための薬剤
特許第4815063号 (2011/09/02)
特  許  出  願: 2001-115999(2001/04/13)
特  許  公  開: 2002-308779(2002/10/23)
発     明    者: 室伏きみ子、阿相皓晃、小林哲幸
出     願    人: 室伏きみ子
9. ピラゾロン誘導体及びテロメラーゼ阻害剤
特許第4629993号(2010/11/19)
特  許  出  願: 2004-106908(2004/03/31)
特  許  公  開: 2005-289874(2005/10/20)
発     明    者: 室伏きみ子、古関千寿子、小野高、垣内康孝
出     願    人: 室伏きみ子
8. カルバ環状ホスファチジン酸誘導体
特許第4162927号 (2008/08/01)
特  許  出  願: 2002-169743 (2002/06/11)
特  許  公  開: 2004-010582(2004/01/15)
発     明    者: 室伏きみ子、向井睦子、小林進、室伏擴
出     願    人: 室伏きみ子
7. カルバ環状ホスファチジン酸誘導体を含む癌転移抑制剤
特許第4163007号 (2008/08/01)(アメリカ、EUでも権利取得済)
特  許  出  願: 特願2002-591003(2002/05/20)
特  許  公  開: 再公表02-094286 (2004/09/02)
国際出願番号: JP2002004839
国際公開番号: WO02094286(2002/11/28)
発     明    者: 向井睦子、小林進、室伏擴、室伏きみ子
出     願    人: 室伏きみ子
6. 環状ホスファチジン酸の製造法
特  許  出  願: 特願平11-367032(1999/12/24)
特  許  公  開: 2001-178489(2001/07/03)
発     明    者: 室伏きみ子
出     願    人: 室伏きみ子
5. 熱ショック蛋白質誘導剤
特許第4322329号(2009- 06/12)
特  許  出  願: 平10-195278 (1998/07/10)
特  許  公  開: 2000-026495(2000/01/25)
発     明    者: 室伏きみ子、小林進、山津功
出     願    人: 室伏きみ子
4. テロメラーゼ
特  許  出  願: 特願平08-282948(1996/10/04)
特  許  公  開: 平09-154575(1997/06/17)
発     明    者: 室伏きみ子
出     願    人: 株式会社そーせい
3. 1-O-アシルグリセロール-2,3-ホスフェート誘導体を有効成分とす るDNAポリメラーゼαの阻害剤
特  許  出  願: 平06-072837(1994/03/18)
特  許  公  開: 平07-258278(199/10/09)
発     明    者: 小林進、今井信行、鬼村謙二郎、品川留美、中村修子、室伏きみ子
出     願    人: 財団法人相模中央化学研究所
2. タンパク質リン酸化酵素Cの活性促進剤
特  許  出  願: 平05-319186(1993/11/26)
特  許  公  開: 平07-149772(1995/06/13)
発     明    者: 小林進、今井信行、鬼村謙二郎、中村修子、室伏きみ子
出     願    人: 財団法人相模中央化学研究所
1. 新規生理活性物質及びその製造法
特許第3195833号 (2001/06/01)
特  許  出  願: 平04-262478(1992/09/30)
特  許  公  開: 平05-230088(1993/09/07)
発     明    者: 室伏きみ子
出     願    人: 室伏きみ子
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